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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TXNRD2 All Species: 5.76
Human Site: S345 Identified Species: 8.44
UniProt: Q9NNW7 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NNW7 NP_006431.2 524 56507 S345 T Q K I L V D S R E A T S V P
Chimpanzee Pan troglodytes XP_001166615 481 51948 I315 F D T V L W A I G R V P D T R
Rhesus Macaque Macaca mulatta NP_001152971 524 56314 S345 T Q K I L V D S R E G T S V P
Dog Lupus familis XP_850181 509 55065 A332 S Q K I L V N A Q E A T S I P
Cat Felis silvestris
Mouse Mus musculus Q9JLT4 524 56434 A345 N Q K I I V D A Q E A T S V P
Rat Rattus norvegicus Q9Z0J5 526 56406 A347 N Q K I I V D A Q E A T S V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001116163 518 56137 A339 T G K I I V D A S E A T S V P
Frog Xenopus laevis NP_001080052 504 54666 A325 T G K I I V D A S E A T S V P
Zebra Danio Brachydanio rerio NP_898895 602 65949 P420 N E K N G K V P V N D E E Q T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91938 596 64304 E419 K I P V D S Q E A T N V A N I
Honey Bee Apis mellifera NP_001171496 537 59227 E360 A K I D A I D E Q T N V P N V
Nematode Worm Caenorhab. elegans Q17745 667 74094 K478 T I G V E R A K S K K V L G R
Sea Urchin Strong. purpuratus XP_797733 490 53044 Q316 K V M G S N E Q S S V P H I H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P48641 499 53852 D323 Q A G A V K V D E Y S R T N I
Baker's Yeast Sacchar. cerevisiae P41921 483 53422 N305 H L G M G S E N V G I K L N S
Red Bread Mold Neurospora crassa Q873E8 468 50294 Y304 G Y I E V D E Y Q N T S T E N
Conservation
Percent
Protein Identity: 100 91 98.2 83.2 N.A. 84.5 82.6 N.A. N.A. 72.9 68.6 47 N.A. 48.9 53 40.7 55.7
Protein Similarity: 100 91.2 99 91.4 N.A. 91.5 90.8 N.A. N.A. 86 82.2 62.2 N.A. 62.4 68.5 56.2 69.8
P-Site Identity: 100 6.6 93.3 66.6 N.A. 73.3 73.3 N.A. N.A. 73.3 73.3 6.6 N.A. 0 6.6 6.6 0
P-Site Similarity: 100 13.3 93.3 100 N.A. 93.3 93.3 N.A. N.A. 86.6 86.6 13.3 N.A. 13.3 26.6 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. 33.7 32.8 34.7
Protein Similarity: N.A. N.A. N.A. 51.7 53 52.4
P-Site Identity: N.A. N.A. N.A. 0 0 0
P-Site Similarity: N.A. N.A. N.A. 20 20 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 7 7 0 13 32 7 0 38 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 7 7 7 44 7 0 0 7 0 7 0 0 % D
% Glu: 0 7 0 7 7 0 19 13 7 44 0 7 7 7 0 % E
% Phe: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 13 19 7 13 0 0 0 7 7 7 0 0 7 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 0 7 0 7 % H
% Ile: 0 13 13 44 25 7 0 7 0 0 7 0 0 13 13 % I
% Lys: 13 7 50 0 0 13 0 7 0 7 7 7 0 0 0 % K
% Leu: 0 7 0 0 25 0 0 0 0 0 0 0 13 0 0 % L
% Met: 0 0 7 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 19 0 0 7 0 7 7 7 0 13 13 0 0 25 7 % N
% Pro: 0 0 7 0 0 0 0 7 0 0 0 13 7 0 44 % P
% Gln: 7 32 0 0 0 0 7 7 32 0 0 0 0 7 0 % Q
% Arg: 0 0 0 0 0 7 0 0 13 7 0 7 0 0 13 % R
% Ser: 7 0 0 0 7 13 0 13 25 7 7 7 44 0 7 % S
% Thr: 32 0 7 0 0 0 0 0 0 13 7 44 13 7 7 % T
% Val: 0 7 0 19 13 44 13 0 13 0 13 19 0 38 7 % V
% Trp: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 7 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _